Everything about Chlorogenic Acid totally explained
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Chlorogenic acid is a family of
esters formed between certain
trans cinnamic acids and (-)-
quinic acid and is a major
phenolic compound in
coffee, found widespread in plants, and can be isolated from the leaves and fruit. This compound, long known as an
antioxidant, also slows the release of
glucose into the
bloodstream after a meal.
Chemical properties
Structurally, chlorogenic acid (CGA) is the
ester formed between certain trans
cinnamic acid and
(L)-
quinic acid (1L-1(OH),3,4/5-tetrahydroxycyclohexane
carboxylic acid).
Isomerisation of chlorogenic acid have been reported with 3 isomerisations of the quinic acid in position 3, (3-CQA), 4 (4-CGA) and 5 (5-CQA). Isomerisation at position 1 and 6 hasn't yet been reported. and cardiovascular disease.
Pharmaceutical & industrial applications
This substance is claimed to have antiviral, antibacterial and antifungal effects with relatively low toxicity and side effects, alongside properties that don't lead antimicrobial resistance. Potential uses are suggested in pharmaceuticals, foodstuffs, feed additives, and cosmetics.
Chlorogenic acid is marketed under the tradename Svetol in Norway and the United Kingdom as a food active ingredient used in coffee, chewing gum, and mints to promote weight reduction.
Recent studies
Chlorogenic acid has been proven in animal studies
in vitro to inhibit the
hydrolysis of the glucose-6-phosphate enzyme in an irreversible fashion. This mechanism allows chlorogenic acid to reduce
hepatic glycogenolysis (transformation of glycogen into glucose) and to reduce the absorption of new
glucose. In addition,
in vivo studies on animal subjects have demonstrated that the administration of chlorogenic acid lessens the
hyperglycemic peak resulting from the glycogenolysis brought about by the administering of glucagon, a hyperglycemiant hormone. The studies also confirmed a reduction in blood glucose levels and an increase in the intrahepatic concentrations of glucose-6-phosphate and of
glycogen.
Further Information
Get more info on 'Chlorogenic Acid'.
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